Journal article
Genetics of microstructure of the corpus callosum in older adults
SC Kanchibhotla, KA Mather, A Thalamuthu, L Zhuang, PR Schofield, JBJ Kwok, D Ames, MJ Wright, JN Trollor, W Wen, PS Sachdev
Plos One | PUBLIC LIBRARY SCIENCE | Published : 2014
Abstract
The current study sought to examine the relative influence of genetic and environmental factors on corpus callosum (CC) microstructure in a community sample of older adult twins. Analyses were undertaken in 284 healthy older twins (66% female; 79 MZ and 63 DZ pairs) from the Older Australian Twins Study. The average age of the sample was 69.82 (SD54.76) years. Brain imaging scans were collected and DTI measures were estimated for the whole CC as well as its five subregions. Parcellation of the CC was performed using Analyze. In addition, white matter lesion (WMLs) burden was estimated. Heritability and genetic correlation analyses were undertaken using the SOLAR software package. Age, sex, s..
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Grants
Awarded by National Institute of Biomedical Imaging and Bioengineering
Funding Acknowledgements
OATS is supported by the NHMRC/Australian Research Council Strategic Award 401162 and NHMRC Project Grant 1045325. OATS was facilitated through access to the Australian Twin Registry, a national research resource supported by the NHMRC Enabling Grant 310667, administered by the University of Melbourne. Sri Chandana Kanchibhotla is supported by a scholarship from the Dementia Collaborative Research Centre (DCRC). Karen Mather is supported by an Alzheimer's Australia Dementia Research Foundation Postdoctoral Fellowship and the NHMRC Capacity Building Grant 568940. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.